Granulation using roller compaction is commonly known as dry compaction. This process avoids the requirement for additional binders or liquids, which are necessary in the wet granulation process, and as a consequence of the wetting process a drying phase is also required. Since no wetting takes place in roller compaction the product is not subject to chemical reactions or high temperature drying. In addition the benefit of reduced environmental impact is achieved by dry compaction. The compaction of the materials is realized by high mechanical pressing forces, which provide the production of a compressed ribbon.
The processing principle of roller compaction and granulation is relatively straight forward. However, only the use of modern production technology in connection with highly-developed feeding and control technology enables an accurate and economic production of high quality roller compacted and granulated products, which meet pharmaceutical requirements.